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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

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Transient rest restores functionality in exhausted CAR-T cells through  epigenetic remodeling
Cancers, Free Full-Text

Cancers, Free Full-Text

Evan Weber - Assistant Professor - University of Pennsylvania

Evan Weber - Assistant Professor - University of Pennsylvania

T-cell engineering strategies for tumors with low antigen density

T-cell engineering strategies for tumors with low antigen density

How To Give CAR-T Cells a Boost

How To Give CAR-T Cells a Boost

Brilliant Violet 711(TM) anti-T-bet 644819 from BioLegend

Brilliant Violet 711(TM) anti-T-bet 644819 from BioLegend

Transient “rest” induces functional reinvigoration and epigenetic

Transient “rest” induces functional reinvigoration and epigenetic

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced  dysfunction

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Rested CAR-T cells exhibit wholescale remodeling of the

Rested CAR-T cells exhibit wholescale remodeling of the

Frontiers  Mechanisms of CAR T cell exhaustion and current counteraction  strategies

Frontiers Mechanisms of CAR T cell exhaustion and current counteraction strategies

Transient “rest” induces functional reinvigoration and epigenetic

Transient “rest” induces functional reinvigoration and epigenetic

Frontiers  Combination strategies to optimize the efficacy of

Frontiers Combination strategies to optimize the efficacy of

CAR-T Cells, PDF, Proteomics

CAR-T Cells, PDF, Proteomics

/files/Articles/780442/fimmu-12

/files/Articles/780442/fimmu-12

CAR-T Cells, PDF, Proteomics

CAR-T Cells, PDF, Proteomics