Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment, Chinese Medicine

Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro. Recently, much attention has been paid to the therapeutic role of artemisinin in liver diseases. Several studies suggest that artemisinin and its derivatives can protect the liver through different mechanisms, such as those pertaining to inflammation, proliferation, invasion, metastasis, and induction of apoptosis and autophagy. In this review, we provide a comprehensive discussion of the underlying molecular mechanisms and signaling pathways of artemisinin and its derivatives in treating liver diseases. Further pharmacological research will aid in determining whether artemisinin and its derivatives may serve as promising medicines for the treatment of liver diseases in the future.

Commercialized artemisinin derivatives combined with colistin protect against critical Gram-negative bacterial infection

Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms

El-Megharbel: Chemical and spectroscopic characterization of (Artemisinin/Quercetin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by

Artemisia Annua: 6 Benefits, Dosage, & Safety, artemisia annua

Novel use for old drugs: The emerging role of artemisinin and its derivatives in fibrosis - ScienceDirect

Pharmacology of Antimalarial Drugs, Current Anti-malarials

Frontiers Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

Artemisia Annua: 6 Benefits, Dosage, & Safety, artemisia annua

Antimalarial drug discovery: progress and approaches

New clinical application prospects of artemisinin and its derivatives: a scoping review, Infectious Diseases of Poverty